The expanded occurrence of weight, diabetes, and cardiovascular risk factors in people hospitalized with extreme COVID-19 infection has incited impressive interest within the metabolic parts of SARS-CoV-2-initiated pathophysiology. The metabolic issues and their co-morbidities modify the susceptibility to, normal history, and likely treatment of SARS-CoV-2 disease, with an emphasis on human science. New information educating hereditary inclination, the study of disease transmission, invulnerable reactions, infection seriousness, and treatment of COVID-19 in people with obesity and diabetes are featured.