The study's goal was to compare clinical hygiene indicators, patient collaboration, and oral practises in ASD (Autism Spectrum Disorder) individuals before and after a customised preventative programme. A total of 100 patients (78 boys and 22 females, mean age 80.7 years) with ASD diagnosis were enrolled, ranging in age from 7 to 16 years old. For each patient, we calculated the Index Plaque (IP), gingival in-dex (IG), dmft/DMFT, dental brushing frequency, and snack frequency. The Frankl scale was used to assess patient behaviour, and each patient was examined individually after five visits by the same operator. To compare the parameters before and after inclusion in the specific dental pathway, the t test was performed. We discovered a substantial improvement in the IP (p0.001), IG (p0.001), and teeth brushing frequency (p0.001) from T1 to T2. The differences in the observed averages for snack frequency and the metric dmft/DMFT were not significant (p>0.05). The Frankl scale revealed a statistically significant difference in collaboration between T1 and T2 (p0.001). The preventative programme was proven to have a considerable impact on clinical.