Anomalous muscles are often a matter of concern to clinicians as they mislead the diagnosis. Knowledge of such variant muscles is important clinically to avoid misdiagnosis. In this report we present an anomalous muscle on the dorsum of hand, extensor digitorum brevis manus an uncommon variation present as a swelling on the dorsum. It is originated from the dorsal wrist capsule within the compartment deep to the extensor retinaculum for the extensor digitorum and inserted into the extensor hood of the index finger, this variant muscle often cause dorsal wrist pain and often confused as ganglion, soft tissue tumor, synovial cyst or tenovaginitis. The presence of such variant muscles on dorsum of hand, their clinical significance and literature has been reviewed.
